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Updated: Jul 5, 2026
05:51
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[Schizophrenia and evolutionary psychopathology].
1Bács-Kiskun Megyei Kórház, Pszichiátriai Osztály, Kecskemét, Hungary. kelemeno@kmk.hu
Summary
Evolutionary paradoxes in schizophrenia are explored, examining if it's a byproduct of human brain evolution or offers compensatory advantages. Theories linking psychosis to shamanism and religion are also discussed.
Area of Science:
- Evolutionary psychiatry
- Genetics of mental disorders
- Neuroscience
Context:
- Schizophrenia presents a paradox due to its persistence across cultures despite reproductive disadvantages.
- The stress-diathesis model highlights the genetic underpinnings of psychiatric disorders, suggesting evolutionary relevance.
Purpose:
- To review major evolutionary theories explaining the origins of schizophrenia.
- To analyze proposed evolutionary disadvantages and compensatory advantages associated with schizophrenia.
- To critically evaluate theories linking psychosis, shamanism, and religion to schizophrenia's origins.
Summary:
- Schizophrenia's persistence challenges evolutionary theory, prompting investigation into its origins.
- Theories suggest schizophrenia may be a byproduct of human brain evolution (e.g., language, social brain) or confer advantages (e.g., disease resistance, creativity).
- The article details and debates theories connecting shamanism and religion to psychotic experiences and schizophrenia's evolutionary basis.
Impact:
- Provides a comprehensive overview of evolutionary perspectives on schizophrenia.
- Facilitates understanding of the complex interplay between evolution, genetics, and mental health.
- Offers insights into potential selective pressures and adaptive mechanisms related to schizophrenia.
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