Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ankle Joint01:10

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does a "Western Lifestyle" Confer a Higher Burden of Colorectal Cancer? A Comparison of EU15+ Countries versus Global Trends between 1990 and 2019.

Cancers·2024
Same author

A More Accurate Measurement of the Burden of Coronavirus Disease 2019 Hospitalizations.

Open forum infectious diseases·2022
Same author

Oral Is the New IV. Challenging Decades of Blood and Bone Infection Dogma: A Systematic Review.

The American journal of medicine·2021
Same author

Dynamic mapping of the corticospinal tract in open cordotomy and myelomeningocele surgery.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2020
Same author

Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS.

Annals of clinical and translational neurology·2018
Same author

Trends in Narcotic and Corticosteroid Prescriptions in Patients with Inflammatory Bowel Disease in the United States Ambulatory Care Setting from 2003 to 2011.

Inflammatory bowel diseases·2017
Same journal

Which Factors Are Associated With Death, Local Recurrence, and Perioperative Complications After En Bloc Resection for Primary Malignant Tumors of the Mobile Spine?

Clinical orthopaedics and related research·2026
Same journal

Impact Microindentation Evaluates Bone Strength, Bone Quality, and Fracture Susceptibility Across Skeletal Sites: A Cadaver Study.

Clinical orthopaedics and related research·2026
Same journal

What Is the Effect of Robot Reduction in Displaced Pelvic Fractures? A Multicenter Randomized Clinical Trial.

Clinical orthopaedics and related research·2026
Same journal

CORR Insights®: Acute or Delayed TKA for Tibial Plateau Fracture? An Observational Study From the Swedish Arthroplasty Register.

Clinical orthopaedics and related research·2026
Same journal

Reply to the Letter to the Editor: Guest Editorial: Recalling a Recall.

Clinical orthopaedics and related research·2026
Same journal

Radial Head Fractures Cluster in the Anterolateral and Anteromedial Quadrants and Do Not Correlate With Coronoid Fracture Types.

Clinical orthopaedics and related research·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2026

Knee Arthrocentesis in Adults
04:41

Knee Arthrocentesis in Adults

Published on: February 25, 2022

Hematogenous septic ankle arthritis.

Paul D Holtom1, Lawrence Borges, C G Zalavras

  • 1Department of Orthopaedics, Keck School of Medicine, University of Southern California, 1200 N State Street, Room 3900, Los Angeles, CA 90033, USA. holtom@usc.edu

Clinical Orthopaedics and Related Research
|April 19, 2008
PubMed
Summary
This summary is machine-generated.

Hematogenous septic arthritis of the ankle is often caused by Staphylococcus aureus. Adjacent osteomyelitis occurs in 30% of cases, particularly in patients with comorbidities, necessitating high clinical suspicion.

Related Experiment Videos

Last Updated: Jul 5, 2026

Knee Arthrocentesis in Adults
04:41

Knee Arthrocentesis in Adults

Published on: February 25, 2022

Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Microbiology

Background:

  • Ankle infections present significant challenges due to limited data on microbiology and associated morbidities.
  • Hematogenous septic arthritis of the ankle is a severe condition requiring detailed investigation.

Purpose of the Study:

  • To elucidate the laboratory findings, microbiology, and incidence of adjacent osteomyelitis in patients with hematogenous septic arthritis of the ankle.

Main Methods:

  • Retrospective review of 30 patients with hematogenous septic arthritis of the ankle over a 10-year period.
  • Analysis of laboratory markers, microbiological cultures, and imaging for osteomyelitis.
  • Correlation of osteomyelitis with patient comorbidities.

Main Results:

  • Staphylococcus aureus was the predominant pathogen (54%), including oxacillin-resistant strains (17%).
  • Mycobacterial infection was identified in 17% of positive cultures.
  • Adjacent osteomyelitis was present in 30% of patients, significantly associated with comorbidities.
  • Elevated C-reactive protein and erythrocyte sedimentation rate were universal, but peripheral white blood cell count was elevated in only 47%.

Conclusions:

  • Staphylococcus aureus is the most common pathogen in septic ankle arthritis, supporting empiric antibiotic therapy.
  • Adjacent osteomyelitis is a frequent complication, especially in patients with comorbidities, warranting a high index of suspicion.