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[Toxicologic estimation, an element of therapeutical progress].

P E Fournier1

  • 1Hôpital Fernand-Widal, Paris.

Annales Pharmaceutiques Francaises
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Clinical toxicology is crucial for safe and effective drug use, informing dose-response relationships and identifying genetic factors in adverse reactions. It guides the scientific approach to novel therapies, including cytotoxic and bio-drugs.

Area of Science:

  • Clinical toxicology
  • Pharmacogenetics
  • Drug development

Context:

  • Essential for safe clinical use of drugs and medical materials.
  • Informs dose-effect relationships for acute and chronic adverse effects.
  • Differentiates therapeutic efficacy from placebo effects and overdose toxicity.

Purpose:

  • To understand individual responses to xenobiotics, including genetic predispositions.
  • To guide the scientific approach to novel therapies like cytotoxic and bio-drugs.
  • To address the toxicological challenges posed by new biotechnologies and synthetic chemicals.

Summary:

  • Clinical toxicology is vital for understanding drug efficacy and safety, including dose-response and adverse effects.
  • It encompasses toxicogenetics and pharmacogenetics for personalized medicine.

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  • Requires specific toxicological studies for emerging therapies like cytotoxic drugs and bio-drugs.

    • Impact:

    • Enables better clinical application of drugs and biomaterials.
    • Facilitates the development of safer and more effective therapeutic strategies.
    • Highlights the need for rigorous toxicological evaluation of all chemical entities used in medicine.