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Updated: Jul 5, 2026

Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica
Published on: August 23, 2018
Carboxamides combining favorable olfactory properties with insect repellency
Jean-Marc Gaudin1, Thierry Lander, Olga Nikolaenko
1Firmenich SA, Corporate R&D Division, P.O. Box 239, CH-1211 Geneva 8. jean-marc.gaudin@firmenich.com
Abstract:
By a simple methodology, we have synthesized 68 carboxamides, with structural analogy to the most efficient mosquitoes repellent DEET (N,N-diethyl-m-toluamide, 9). Eight of them have very promising olfactory profiles. In addition, 34 carboxamides have been tested for their repellency properties against three breeds of cockroach; six of them are excellent in this domain. Two of these, the 2-ethyl-N-isopropyl-N-methylbutanamide and N,N-diallyl-2-ethylbutanamide combine both the positive aspects, and are thus very good candidates for use in functional perfumery, and more particularly in home-care formulations.
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