Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extremity epithelioid sarcoma. Amputation vs local resection.

P W Whitworth1, R E Pollock, P F Mansfield

  • 1Department of General Surgery, University of Texas M. D. Anderson Cancer Center, Houston 77036.

Archives of Surgery (Chicago, Ill. : 1960)
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical practice variation and outcomes regarding single-level posterior approach for degenerative lumbar spondylolisthesis: a Canadian Spine Outcomes Research Network (CSORN) study.

The spine journal : official journal of the North American Spine Society·2025
Same author

Growth and form of a self-constructing tube network.

Chaos (Woodbury, N.Y.)·2020
Same author

Temporal Dynamics of Wheat Blast Epidemics and Disease Measurements Using Multispectral Imagery.

Phytopathology·2019
Same author

Verticillin A Inhibits Leiomyosarcoma and Malignant Peripheral Nerve Sheath Tumor Growth via Induction of Apoptosis.

Clinical & experimental pharmacology·2017
Same author

The medical bookshelf.

Postgraduate medicine·2016
Same author

Improved Survival with Anti-VEGF Therapy in the Treatment of Unresectable Appendiceal Epithelial Neoplasms.

Annals of surgical oncology·2015
Same journal

The White Test: A New Dye Test for Intraoperative Detection of Bile Leakage During Major Liver Resection-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Use of Vascular Clamping in Hepatic Surgery: Lessons Learned From 1260 Liver Resections-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Randomized Clinical Trial of Small-Incision and Laparoscopic Cholecystectomy in Patients With Symptomatic Cholecystolithiasis: Primary and Clinical Outcomes-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Liver Resection With a New Multiprobe Bipolar Radiofrequency Device-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Porcine and Bovine Surgical Products: Jewish, Muslim, and Hindu Perspectives-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Neuroendocrine Liver Metastasis: Transplant as Part of Multimodality Liver-Directed Therapy-Reply.

Archives of surgery (Chicago, Ill. : 1960)·2016
See all related articles

Radical amputation is not always necessary for epithelioid sarcoma of the extremity. Wide local excision with clear margins offers a favorable outcome for localized disease, challenging traditional treatment approaches.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Orthopedic Oncology

Background:

  • Epithelioid sarcoma traditionally prompts amputation due to its metastatic potential.
  • The efficacy of amputation versus limb-sparing surgery for extremity epithelioid sarcoma requires evaluation.

Purpose of the Study:

  • To assess the role and outcomes of amputation versus local excision in treating extremity epithelioid sarcoma.
  • To compare survival rates and disease-free status based on surgical intervention.

Main Methods:

  • Retrospective review of 42 patients with extremity epithelioid sarcoma treated between 1961 and 1986.
  • Analysis of treatment modalities including wide local excision, excisional biopsy, and amputation.
  • Evaluation of outcomes based on disease presentation: localized primary tumor, localized recurrence, and regional metastasis.

Related Experiment Videos

Main Results:

  • For localized primary tumors, wide local excision (WLE) and excisional biopsy showed high rates of disease-free survival, while amputation resulted in death.
  • For localized recurrence, WLE and excisional biopsy also demonstrated favorable outcomes, even with positive margins in some WLE cases.
  • In cases of regional metastasis, both WLE and amputation yielded poor disease-free survival rates, with no clear benefit from amputation.

Conclusions:

  • Wide local excision with negative margins is preferable to radical amputation for localized epithelioid sarcoma.
  • Amputation does not appear to offer a survival benefit for patients presenting with regional metastasis.
  • Limb-sparing surgical techniques should be considered for localized extremity epithelioid sarcoma.