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Updated: Jul 5, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
[Syncope in infants and adolescents]
1Centro de Neuropediatria, Hospital de Clínicas, Departamento de Pediatria da Universidade Federal do Paraná, Curitiba, Paraná, Brasil. antoniuk@uol.com.br
Insights
Syncope, or fainting, is common in children and adolescents. While often benign and caused by vasovagal responses, it can signal serious conditions, necessitating accurate diagnosis and tailored treatment.
Area of Science:
- Pediatric Cardiology
- Neurology
- Clinical Medicine
Context:
- Syncope is a frequent clinical presentation in infants and adolescents.
- It is characterized by transient loss of consciousness and postural tone, with rapid recovery.
- While often benign, syncope can indicate severe underlying neurological, cardiac, or metabolic conditions.
Purpose:
- To review the etiology, clinical manifestations, pathophysiology, diagnostic methods, and treatment of syncope in pediatric populations.
- To highlight the importance of accurate diagnosis for effective management.
- To differentiate between benign and potentially life-threatening causes of syncope.
Summary:
- Neurocardiogenic (vasovagal) syncope is the most common cause in this age group, typically with a benign outcome.
- Diagnostic evaluation relies heavily on clinical history and physical examination, supplemented by basic tests like ECG, glucose, and electrolyte levels.
- The Tilt Table Test is crucial for confirming neurocardiogenic syncope.
Impact:
- Early and accurate diagnosis is critical for implementing specific and timely treatment, improving patient outcomes.
- Treatment strategies range from preventive measures and education to pharmacological interventions (e.g., beta-blockers, fludrocortisone) and, in severe cases, pacemaker implantation.
- Understanding the diverse etiologies of syncope is essential for managing prognosis, which can vary from benign to potentially lethal.
Aim:
To review the syncope in infants and adolescents as well as its etiology, clinical manifestations, physiopathology, diagnostic methods and treatment.
Development:
The syncope is a clinical entity characterized by sudden and transient loss of consciousness and postural tone, with a quick and complete recovery. The syncope is frequent in children and adolescents. The most common cause is neurocardiogenic (vasovagal), which has a benign evolution. Other causes may be neurological, cardiac and metabolic diseases, with a variable prognosis, which may come to be severe and potentially lethal. Evaluation of the syncope is mainly based on present clinical history, and on a detailed clinical examination. Basic complementary exams may help on the diagnosis, as a glycemia test, determination of electrolytes (sodium, potassium, magnesium), a hemogram and an electrocardiogram. The Tilt Test is "the" test to confirm the neurocardiogenic syncope. Treatment is indicated in syncopes with recurrent episodes or with risk of physical lesions. Prevention and education are indicated for all patients. Specific treatment should be individually given to each patient. In the case of neurocardiogenic syncope, beta-blockers, alpha-adrenergic stimulants, serotonin reuptake inhibitors, and fludrocortisone are used. In the frequently recurrent neurocardiogenic syncope, when preventive actions are not enough or there is risk of lesions in consequence of falls, beta-blockers, alpha-adrenergic stimulants, serotonin reuptake inhibitors, and fludrocortisone are used, as well as a pacemaker for severe cases non-responsive to pharmacological treatment.
Conclusion:
The syncope is a frequent clinical entity in infancy and adolescence, with benign evolution but potentially lethal. Diagnosis and correct etiology are important for the implementation of specific and early treatment.
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