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Updated: Jul 5, 2026

Constitutive and Inducible Systems for Genetic In Vivo Modification of Mouse Hepatocytes Using Hydrodynamic Tail Vein Injection
Published on: February 2, 2018
[Alternatively spliced variants of constitutive androstane receptor in liver of mouse]
Hong-Ying Sun1, Jing Chen, Kai Jiang
1Institute of Pharmacology, Toxicology and Biopahrm, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Objective:
To investigate the existence of alternatively spliced variants of constitutive androstane receptor (CAR) in liver of mouse.
Methods:
The nucleotide from liver of mouse was purified and the CAR cDNA was amplified by PCR. The fragments of CAR cDNA were cloned to T vector and sequence analysis was performed.
Result:
Various spliced variants of CAR in liver mouse were confirmed by DNA sequencing.
Conclusion:
There are alternatively spliced variants in CAR, which are located in the ligand binding sequence of CAR.
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