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Methicillin-oxacillin resistant strains of Staphylococcus aureus (MORSA) in infected burn wounds
B Polaczek-Kornecka1, Z Dziadur-Goldsztaj, G Turowski
1Third Department of General Surgery, Copernicus University School of Medicine, Kraków, Poland.
Abstract:
Among 204 strains isolated from infected burn wounds of 188 patients in the years 1987-1989 resistance to methicillin and oxacillin was found in 116 Staphylococcus aureus strains (group A). They accounted for 56.6% of the isolates. These data were compared with those of 1815 strains isolated from surgical cases in which 901 were MORSA strains (group B). In both groups MORSA were tested for their sensitivity to 9 various antibiotics. They were most sensitive to vancomycin and cefamandole.
Insights
Methicillin and oxacillin-resistant Staphylococcus aureus (MORSA) strains were prevalent in burn wound and surgical infections between 1987-1989. These resistant bacteria showed the highest sensitivity to vancomycin and cefamandole antibiotics.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Staphylococcus aureus is a common cause of hospital-acquired infections.
- Methicillin and oxacillin resistance in Staphylococcus aureus (MORSA) poses a significant therapeutic challenge.
- Prevalence of MORSA in clinical settings requires ongoing surveillance.
Purpose of the Study:
- To determine the prevalence of MORSA in infected burn wounds and surgical cases.
- To compare MORSA rates between burn wound and surgical site infections.
- To evaluate the antibiotic sensitivity profile of MORSA isolates.
Main Methods:
- Isolation and identification of Staphylococcus aureus strains from patient samples.
- Phenotypic detection of methicillin and oxacillin resistance.
- Antimicrobial susceptibility testing against nine different antibiotics.
Main Results:
- 116 out of 204 strains (56.6%) from burn wounds were identified as MORSA (Group A).
- Comparison with 901 MORSA strains from surgical cases (Group B) revealed significant prevalence in both settings.
- MORSA isolates demonstrated highest sensitivity to vancomycin and cefamandole.
Conclusions:
- MORSA strains represent a substantial proportion of Staphylococcus aureus infections in both burn wounds and surgical sites.
- Vancomycin and cefamandole are effective therapeutic options against MORSA isolates identified in this study.
- Continued monitoring of antimicrobial resistance patterns is crucial for effective infection control.