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Tolterodine for the treatment of overactive bladder
Stefano Salvatore1, Maurizio Serati, Pierfrancesco Bolis
1University of Insubria, Department of Obstetrics and Gynecology, Del Ponte Hospital, Via Ciro Menotti 76, 21100 Varese, Italy. stefanosalvatore@hotmail.com
Background:
The overactive bladder syndrome is a common condition affecting approximately 12% of men and women. It is extremely disturbing with a great impact on quality of life. Its treatment involves a combination of behavioural and pharmacological therapy. The latter includes antimuscarinic drugs such as tolterodine.
Objective:
To review the safety and efficacy of tolterodine in the treatment of overactive bladder in comparison with other available antimuscarinic agents.
Methods:
A Pubmed search was carried out differentiating randomised, clinical trials; longitudinal, retrospective studies; and metanalysis on the use of tolterodine for overactive bladder treatment. In the comparison with other antimuscarinic agents, only randomised, clinical trials were considered.
Results/Conclusion:
Tolterodine is available as immediate- or extended-release formulations. It has been extensively evaluated with long-term, randomised trials for safety and efficacy showing a significant improvement in overactive bladder symptoms with an excellent tolerability profile.
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