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Updated: Jul 5, 2026
09:03
Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
Published on: March 10, 2020
PRRDB: a comprehensive database of pattern-recognition receptors and their ligands
Sneh Lata1, Gajendra P S Raghava
1Institute of Microbial Technology, Sector39A, Chandigarh, India. sneh@imtech.res.in
BMC Genomics
|April 22, 2008
Summary
The PRRDB database consolidates information on pattern recognition receptors (PRRs) and their ligands, crucial for understanding innate immunity. This resource aids in developing vaccines and elucidating immune system functions.
Area of Science:
- Immunology
- Bioinformatics
- Molecular Biology
Background:
- The innate immune system provides critical signals for adaptive immune responses.
- Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs).
- A comprehensive database, PRRDB, has been developed to assist the scientific community.
Purpose of the Study:
- To create a centralized resource for pattern recognition receptors and their ligands.
- To support research in innate immunity and vaccine development.
Main Methods:
- Database development and curation.
- Integration of web tools for searching, browsing, and BLAST analysis.
- Linking to external databases such as Swiss-Prot and PubMed.
Main Results:
- The database contains approximately 500 PRRs from 77 organisms.
- Includes 177 Toll-like receptors, 124 Scavenger receptors, and 67 Nucleotide Binding Site-Leucine rich receptors.
- Provides information on 266 ligands and offers integrated search and analysis tools.
Conclusions:
- PRRDB is a unique and comprehensive database for innate immunity research.
- It will be valuable for designing vaccine adjuvants and understanding innate immunity's role.
- The database is publicly accessible.
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