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Updated: Jul 5, 2026

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
Published on: August 30, 2019
KL-6 in acute lung injury: will it leave its mark?
Murali Shyamsundar1, Danny F McAuley
1Research fellow, Royal Victoria hospital/Queen's University of Belfast, Respiratory Research Group, Microbiology Building, Grosvenor Road, Belfast, BT12 6BA.
Abstract:
Studies have indicated that measuring biochemical measures of epithelial injury in plasma and alveolar fluid may be useful in predicting outcome in acute lung injury. The present commentary briefly reviews the evidence supporting the use of these biochemical biomarkers of epithelial injury in acute lung injury, and in particular KL-6, as well as their limitations. The article additionally proposes the need for physiological markers of epithelial function to complement current biochemical biomarkers.
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