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[Efficacy of DACE regimen on relapsed and refractory non-Hodgkin's lymphoma]
Ming-Zhi Zhang1, Wei-Ping Zang, Min Song
1Department of Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, 450052, PR China. mingzhi_zhang@126.com
Background & Objective:
There is no standard salvage regimen for patients with relapsed and refractory non-Hodgkin's lymphoma (NHL) at present. This study was to evaluate the efficacy of DACE regimen, as a salvage regimen, on relapsed and refractory NHL, and observe the adverse events.
Methods:
From May 2001 to May 2006, 61 patients with relapsed and refractory NHL received chemotherapy of DACE regimen: intravenous infusion of cisplatin (20 mg/m(2)) on Days 1-5, etoposide (100 mg) on Days 1-5, cytarabine (150 mg) on Days 1-3, and dexamethone (15 mg/m(2)) on Days 1-5; repeated every 3 weeks. The efficacy and adverse events were evaluated according to the World Health Organization criteria.
Results:
The overall response rates were 63.9% after two cycles of chemotherapy and 72.1% after four cycles. The median remission time lasted 4.7 months (1-58 months). The 1-year survival rate was 29.5%û the 2-year survival rate was 21.3%. Myelosuppression was the major adverse event: the occurrence rate of grade III-IV myelosuppression was 49.1%û it was well tolerated.
Conclusion:
DACE regimen is an effective salvage regimen in treating patients with relapsed and refractory NHL.