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Updated: Jul 5, 2026

Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly
Published on: June 7, 2024
Cytochrome c assembly: a tale of ever increasing variation and mystery?
Stuart J Ferguson1, Julie M Stevens, James W A Allen
1Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. stuart.ferguson@bioch.ox.ac.uk
Abstract:
Formation of cytochromes c requires a deceptively simple post-translational modification, the formation of two thioether bonds (or rarely one) between the thiol groups of two cysteine residues found in a CXXCH motif (with some occasional variations) and the vinyl groups of heme. There are three partially characterised systems for facilitating this post-translational modification; within these systems there is also variation. In addition, there are clear indications for two other distinct systems. Here some of the current issues in understanding the systems are analysed.
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