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Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

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Related Experiment Video

Updated: Jul 5, 2026

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
10:28

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

Adiponectin promotes endothelial progenitor cell number and function.

Rei Shibata1, Carsten Skurk, Noriyuki Ouchi

  • 1Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. rshibata@med.nagoya-u.ac.jp

FEBS Letters
|April 22, 2008
PubMed
Summary
This summary is machine-generated.

Adiponectin, a protein often low in obesity, boosts endothelial progenitor cell (EPC) numbers and function. This suggests adiponectin therapy could help treat cardiovascular disorders linked to low EPC levels.

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Last Updated: Jul 5, 2026

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Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Area of Science:

  • Cardiovascular Research
  • Metabolic Syndrome
  • Cell Biology

Background:

  • Obesity-related diseases are linked to reduced endothelial progenitor cell (EPC) function.
  • Adiponectin, an adipose-derived protein, is downregulated in obese and diabetic individuals.

Purpose of the Study:

  • To investigate the effects of adiponectin on endothelial progenitor cells (EPCs).

Main Methods:

  • Examined EPC levels in adiponectin-deficient (APN-KO) and wild-type (WT) mice following hindlimb ischemia.
  • Utilized adenovirus-mediated delivery of adiponectin in mice.
  • Incubated human peripheral blood mononuclear cells with adiponectin.
  • Assessed EPC differentiation and migration capabilities.

Main Results:

  • Adiponectin administration increased EPC levels in both WT and APN-KO mice.
  • Adiponectin stimulated EPC differentiation into network structures.
  • Adiponectin acted as a chemoattractant, enhancing EPC migration.

Conclusions:

  • Hypoadiponectinemia may contribute to the reduced EPC levels seen in obesity-related cardiovascular disorders.
  • Adiponectin demonstrates therapeutic potential for enhancing EPC function and addressing related cardiovascular risks.