Related Experiment Video
Updated: Feb 16, 2026
09:40
Fast and Efficient Expression of Multiple Proteins in Avian Embryos Using mRNA Electroporation
Published on: June 7, 2019
7.6K
Cell movements driving neurulation in avian embryos
1Department of Anatomy, University of Utah, School of Medicine, Salt Lake City 84132.
Development (Cambridge, England). Supplement
|January 1, 1991
Summary
Epiblast cell movements, including median hinge-point (MHP) and lateral neurepithelial (L) cells, are crucial for neural tube formation during embryogenesis. These cells stream and rearrange, contributing to the shaping and bending of the neural plate.
Area of Science:
- Developmental Biology
- Embryogenesis
- Cellular Morphogenesis
Background:
- Neurulation, the formation of the neural tube, is a critical developmental process.
- It involves diverse cell behaviors like division, shape changes, and rearrangements.
- Epiblast cell movements are key to shaping the neural plate.
Purpose of the Study:
- To investigate the origin and movement of epiblast cells during avian embryogenesis.
- To understand the role of cell movements in neural plate shaping and bending.
- To analyze the contribution of intrinsic and extrinsic forces to neurulation.
Main Methods:
- Utilized quail/chick transplantation chimeras to trace cell origins.
- Employed in situ cell labeling with heritable markers.
- Studied median hinge-point (MHP) and lateral neurepithelial (L) cell populations.
Main Results:
- Identified distinct origins for MHP cells (midline and paranodal epiblast) and L cells (lateral epiblast).
- Observed streaming of MHP cells along the midline neuraxis, driven by cell division and intercalation.
- Documented streaming of L cells along the lateral neuraxis, coordinated with Hensen's node regression.
Conclusions:
- Epiblast cell movements, specifically streaming and intercalation, are fundamental to neural plate morphogenesis.
- Neurulation is a complex process influenced by coordinated cell behaviors and forces.
- Understanding these cell dynamics provides insights into early embryonic development.
Related Concept Videos
01:30Neurulation
46.4K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
46.4K
01:37Energy to Drive Translocation
2.9K
Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
Generally, polypeptides are unfolded by two distinct...
2.9K
00:51Anatomical Movements
16.4K
Anatomical movements refer to the various actions or motions that can be performed by the body's joints and muscles. These movements are described using specific terms to provide a standardized way of discussing and understanding the range of motion at different joints.
Here are some common anatomical movements:
Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist,...
Here are some common anatomical movements:
Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist,...
16.4K
02:15M-Cdk Drives Transition Into Mitosis
6.6K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.6K
01:43The Movement of Organelles and Vesicles
6.6K
In eukaryotic cells, cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
6.6K
01:18Fluid Movement Between Compartments
4.2K
The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
4.2K