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Updated: Jul 5, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
Published on: January 30, 2026
Aging by epigenetics--a consequence of chromatin damage?
John M Sedivy1, Gowrishankar Banumathy, Peter D Adams
1Brown University, Division of Biology and Medicine, Laboratories for Molecular Medicine, 70 Ship Street, Providence, RI 02903, USA. john_sedivy@brown.edu
Abstract:
Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.
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