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Cerebral Hemispheres

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The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

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Updated: Jul 5, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

[Long-term outcome after hemispheric disconnection].

C Bulteau¹, G Dorfmüller, M Fohlen

¹Service de neurochirurgie pédiatrique, fondation ophtalmologique A.-de-Rothschild, 25-29, rue Manin, 75940 Paris cedex 19, France. cbulteau@fo-rothschild.fr

Neuro-Chirurgie

|April 22, 2008

Summary

This summary is machine-generated.

Hemispheric disconnection surgery, like hemispherotomy, offers seizure freedom for 50-80% of epilepsy patients with severe brain pathology. Outcomes vary by cause and technique, but cognitive and social skills often improve.

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Last Updated: Jul 5, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

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Published on: August 16, 2024

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Area of Science:

Neurosurgery
Epileptology
Pediatric Neurology

Context:

Severe epilepsy often stems from congenital or acquired hemispheric brain pathology.
Traditional anatomical hemispherectomy posed risks, leading to the development of safer hemispherotomy techniques.
Hemispheric disconnection is a proposed surgical intervention for intractable epilepsy.

Purpose:

To evaluate the efficacy of hemispheric disconnection in achieving seizure freedom.
To identify factors influencing seizure control and long-term outcomes after surgery.
To explore the impact of hemispheric disconnection on cognitive recovery and brain plasticity.

Summary:

Hemispheric disconnection, particularly hemispherotomy, achieves seizure-free rates of 50-80% in patients with severe hemispheric pathology.
Etiology (e.g., Rasmussen encephalitis, Sturge-Weber syndrome, vascular insults) and surgical technique influence seizure control.
While motor skills may be impacted, communication and socialization skills are often preserved or improve, especially with shorter epilepsy duration.

Impact:

Hemispheric disconnection provides valuable insights into infantile hemispheric specialization and cognitive recovery.
Evidence of cerebral reorganization supports motor and language recovery post-surgery.
Understanding these processes aids in optimizing neurosurgical interventions and rehabilitation strategies.