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Updated: Jul 5, 2026

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
Published on: December 16, 2013
An efficient and practical synthesis of mandelic acid by combination of complex phase transfer catalyst and
1Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A&F University, Yangling, Shaanxi Province 712100, PR China. orgxuhui@nwsuaf.edu.cn
Abstract:
Mandelic acid was synthesized from benzaldehyde with chloroform in a 81% yield at 60 degrees C for 2 h by using triethylbenzylammonium chloride (TEBA) and poly(ethylene glycol)-800 (PEG-800) as a complex phase transfer catalyst under ultrasonic irradiation. The main advantages of this present method are that the reaction time is much shorter and the yield is higher than those of the classical method. p-Methoxymandelic acid was also obtained in a 84% yield under the same reaction conditions.
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