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Activated protein C ratio, plasma tissue factor activity and activated factor VII in Chinese patients with coronary

W J He1, Yu Hu, X P Zhang

  • 1Institute of Hematology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. hwjsun@163.com

European Journal of Medical Research
|April 22, 2008
PubMed

Insights

Abnormal coagulation factors, including low activated protein C ratio and elevated tissue factor activity and activated factor VII, are linked to coronary heart disease (CHD) development in Chinese adults.

Area of Science:

  • Hematology
  • Cardiovascular Disease Research
  • Biochemistry

Background:

  • The coagulation system plays a critical role in hemostasis and thrombosis.
  • Abnormalities in coagulation are associated with the progression of coronary heart disease (CHD).

Purpose of the Study:

  • To evaluate the contribution of hematologic factors and other risk factors to the development of coronary heart disease (CHD).
  • To investigate these factors specifically within the Chinese population.

Main Methods:

  • Enrolled 56 CHD patients and 54 controls.
  • Measured plasma levels of various coagulation factors (e.g., protein C, factor VII, thrombomodulin) using ELISA and automated analyzers.
  • Assessed tissue factor activity (aTF) and activated protein C (APC) ratio.

Main Results:

  • CHD patients showed elevated plasma levels of thrombomodulin, activated factor VII (FVIIa), factor VII:Ag, and aTF compared to controls.
  • The average APC ratio was significantly lower in the CHD group.
  • Binary logistic regression identified elevated activated factor VII and tissue factor activity as risk factors, while high-density lipoprotein and APC ratio were protective.

Conclusions:

  • Low activated protein C ratio, elevated tissue factor activity, and increased activated factor VII are potential contributors to coronary heart disease development.
  • These findings highlight specific hematologic markers relevant to CHD in the studied population.
Abstract

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