Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Two cases of complicated primary hyperparathyroidism during pregnancy].

Innere Medizin (Heidelberg, Germany)·2025
Same author

Music and Rhythm as Promising Tools to Assess and Improve Cognitive Development in Children: A Scoping Review.

Acta paediatrica (Oslo, Norway : 1992)·2025
Same author

Do Antibacterial Skin Sutures Reduce Surgical Site Infections After Elective Open Abdominal Surgery?-A Prospective, Randomized Controlled Single-Center Trial.

Journal of clinical medicine·2024
Same author

Negative Pressure Wound Therapy vs Conventional Wound Treatment in Subcutaneous Abdominal Wound Healing Impairment: The SAWHI Randomized Clinical Trial.

JAMA surgery·2020
Same author

[Non-occlusive Mesenteric Ischemia caused by Diabetic Ketoacidosis - Pneumatosis intestinalis and Portal Venous Gas as an Indication of Mesenteric Ischemia].

Deutsche medizinische Wochenschrift (1946)·2019
Same author

Do antibacterial skin sutures reduce surgical site infections after elective open abdominal surgery? - Study protocol of a prospective, randomized controlled single center trial.

Trials·2019

Related Experiment Video

Updated: Jul 5, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Ischemic preconditioning improves postoperative outcome after liver resections: a randomized controlled study.

Oleg Heizmann1, F Loehe, A Volk

  • 1Department of Surgery, Universitätsspital Basel, Basel, Switzerland. oheizmann@uhbs.ch

European Journal of Medical Research
|April 22, 2008
PubMed
Summary

Ischemic preconditioning (IP) significantly reduces complications and blood loss during liver resection surgery. This protective maneuver is simple to implement in clinical practice, improving patient outcomes after hepatic procedures.

More Related Videos

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
09:22

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

Published on: April 2, 2017

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Related Experiment Videos

Last Updated: Jul 5, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
09:22

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

Published on: April 2, 2017

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Area of Science:

  • Hepatobiliary Surgery
  • Surgical Oncology
  • Transplantation

Background:

  • The Pringle maneuver, used to control bleeding during liver resection, can cause liver injury upon reperfusion.
  • Ischemic preconditioning (IP) shows promise in animal models for protecting the liver from ischemic damage.
  • Clinical evidence for the efficacy of IP in liver surgery remains limited.

Purpose of the Study:

  • To evaluate the clinical effectiveness of ischemic preconditioning (IP) in reducing liver injury and complications during hepatic resection.
  • To determine if IP can mitigate the adverse effects of the Pringle maneuver in patients undergoing liver surgery.

Main Methods:

  • A randomized controlled trial involving 61 patients undergoing liver resection with inflow occlusion.
  • Patients were assigned to receive (Group-A, n=30) or not receive (Group-B, n=31) ischemic preconditioning (10 min ischemia/10 min reperfusion).
  • Outcomes including complications, blood loss, and transfusion requirements were compared between groups.

Main Results:

  • No significant differences in Pringle maneuver duration or resected liver volume between groups.
  • Group-A (IP) experienced significantly fewer complications (6 vs. 14, p<0.05) and less intraoperative blood loss (1.28 vs. 1.94 L, p<0.001).
  • Fewer patients in Group-A required blood transfusions (5 vs. 15, p<0.01).
  • Absence of preconditioning and longer Pringle maneuver duration were independent predictors of postoperative complications.

Conclusions:

  • Ischemic preconditioning (IP) effectively protects against reperfusion injury in liver surgery.
  • IP significantly reduces the incidence of complications following hepatic resection under inflow occlusion.
  • The procedure is straightforward to integrate into clinical practice for liver resection.