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Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

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Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

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Mandibular ossifying fibroma in a dog.

M A Miller¹, H A M Towle, H G Heng

¹Animal Disease Diagnostic Laboratory, Purdue University, 406 S. University Street, West Lafayette, IN 47907, USA. pegmiller@purdue.edu

Veterinary Pathology

|April 22, 2008

Summary

A mandibular mass in a dog, initially diagnosed as osteosarcoma, was reclassified as an ossifying fibroma. Complete surgical excision led to a positive outcome, highlighting the importance of considering ossifying fibroma in canine jaw tumors.

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Area of Science:

Veterinary Pathology
Oral Surgery
Oncology

Background:

Canine mandibular masses require accurate diagnosis for effective treatment.
Osteosarcoma is a common primary bone tumor in dogs, but other fibro-osseous lesions can occur.

Observation:

An aged mongrel dog presented with a mandibular mass initially diagnosed as osteosarcoma.
Histologic examination and anatomic location led to reclassification of the mass as an ossifying fibroma.
The tumor involved the first molar, replacing alveolar and cortical bone.

Findings:

The ossifying fibroma consisted of isomorphic fusiform cells with minimal mitotic activity.
Tumoral stroma featured woven bone trabeculae lined by osteoblasts.
Imaging (CT, radiography) confirmed complete excision with no metastasis.

Implications:

Ossifying fibroma, though less common than osteosarcoma, is a crucial differential diagnosis for canine jaw fibro-osseous lesions.
Complete en bloc excision is recommended for surgical cure of canine ossifying fibroma.
Accurate diagnosis and surgical management contribute to favorable prognosis in canine oral tumors.