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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
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Proteomics: present and future implications in neuro-oncology.

Johann Micallef1, Aaron Gajadhar, Joseph Wiley

  • 1Arthur and Sonia Labatt Brain Tumour Center, Hospital for Sick Children's Research Institute, University of Toronto, Toronto, Canada.

Neurosurgery
|April 22, 2008
PubMed
Summary

Proteomics, the study of proteins, reveals complex variations crucial for individual characteristics and disease, like cancer. Advanced techniques like mass spectrometry aid in understanding these protein networks for therapeutic interventions.

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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Area of Science:

  • Proteomics and Systems Biology
  • Molecular Biology and Genetics

Background:

  • Proteins are essential for cellular structure and function, acting as the genome's "workhorses."
  • Protein function is determined by complex post-transcriptional and post-translational modifications, leading to a proteome far more intricate than the genome.
  • Aberrations in protein function underlie diseases, including cancer, necessitating a deeper understanding of protein networks.

Purpose of the Study:

  • To review emerging proteomic technologies, specifically mass spectrometry and bioluminescence resonance energy transfer.
  • To highlight the application of these proteomic techniques in neuro-oncology research.
  • To emphasize the importance of a systems biology approach in proteomics for understanding normal and abnormal cellular function.

Main Methods:

  • Review of mass spectrometry principles and applications.
  • Review of bioluminescence resonance energy transfer (BRET) principles and applications.
  • Discussion of the integration of these technologies within a systems biology framework.

Main Results:

  • Mass spectrometry and BRET are powerful tools for analyzing complex proteomes.
  • These techniques offer novel insights into protein interactions, localization, and function.
  • Applications in neuro-oncology research demonstrate the potential for understanding disease mechanisms.

Conclusions:

  • Proteomics is vital for deciphering cellular complexity and disease origins.
  • Mass spectrometry and BRET are key technologies advancing proteomic research.
  • Understanding proteomic networks is crucial for developing targeted therapeutic strategies, particularly in neuro-oncology.