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Updated: Feb 15, 2026

Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Intravitreal pegaptanib sodium for refractory pseudophakic macular oedema
E Cervera1, M Diaz-Llopis, P Udaondo
1Department of Ophthalmology, Hospital General de Valencia, Valencia, Spain.
Purpose:
Evaluate the efficacy of intravitreal pegaptanib sodium (Macugen) in refractory pseudophakic cystoid macular oedema (CME).
Design And Methods:
Prospective, nonrandomized, interventional case series. Four eyes of four patients with refractory pseudophakic CME to pars plana vitrectomy and intravitreal bevacizumab and triamcinolone, were treated with pegaptanib sodium, with a mean follow up of 4 months. Pre- and postinfection examinations included assessment of best-corrected visual acuity (BCVA) using the Early Treatment Diabetic Retinopathy Study chart (ETDRS), fluorescein angiography (FA), and optical coherence tomography (OCT).
Results:
Visual acuity increased in all patients after intravitreal pegaptanib sodium. OCT showed improvement of the retinal thickness in the macular area.
Conclusion:
Intravitreal pegaptanib sodium (Macugen) is a promising treatment for pseudophakic cystoid macular oedema resistant to other medical treatment strategies. However, further study is needed to assess the treatment's long term efficacy and the need for retreatment.
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