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Related Experiment Video

Updated: Jul 5, 2026

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Published on: February 3, 2026

Interventions for emergency contraception.

L Cheng¹, A M Gülmezoglu, G Piaggio

¹China Welfare Institute, International Peace Maternity and Child Health Hospital (IPMCH), 145 Guangyuan Road, 910 Hengshan Road, Shanghai, China, 200030. linanc@online.sh.cn

The Cochrane Database of Systematic Reviews

|April 22, 2008

Summary

Mid-dose mifepristone is the most effective emergency contraceptive, outperforming levonorgestrel and the Yuzpe regimen. Copper IUDs also offer effective emergency contraception and ongoing birth control.

Related Experiment Videos

Last Updated: Jul 5, 2026

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Published on: February 3, 2026

Area of Science:

Reproductive Health
Pharmacology
Clinical Trials

Background:

Emergency contraception (EC) prevents pregnancy after unprotected intercourse using drugs or copper IUDs.
Comparative data on EC efficacy, safety, and convenience is vital for healthcare providers and patients.

Purpose of the Study:

To identify the most effective, safe, and convenient emergency contraceptive method for preventing pregnancy after unprotected intercourse.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials and controlled clinical trials.
Searched multiple databases including Cochrane, Popline, MEDLINE, PubMed, Embase, and specialized EC databases.
Data extraction and quality assessment performed independently by two reviewers; meta-analysis used fixed-effects model, with random-effects model for heterogeneity.

Main Results:

Eighty-one trials involving 45,842 women were analyzed; most trials were from China.
Mid-dose mifepristone (25-50 mg) showed superior efficacy compared to levonorgestrel and low-dose mifepristone.
Levonorgestrel was more effective than the Yuzpe regimen; copper IUDs were also effective.
Delayed menses was the primary side effect of mifepristone, appearing dose-dependent.

Conclusions:

Mid-dose mifepristone (25-50 mg) is the most effective hormonal emergency contraceptive.
Levonorgestrel is more effective than the Yuzpe regimen.
Copper intrauterine devices (Cu-IUDs) provide effective emergency contraception and continuous contraception.