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Rocuronium versus succinylcholine for rapid sequence induction intubation.

Jeffrey J Perry1, Jacques S Lee, Victoria A H Sillberg

  • 1Clinical Epidemiology Programme, Ottawa Hospital, 1053 Carling Avenue, Ottawa, Ontario, Canada, K1Y 4E9.

The Cochrane Database of Systematic Reviews
|April 22, 2008
PubMed
Summary
This summary is machine-generated.

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Succinylcholine provides better intubating conditions than rocuronium during rapid sequence induction (RSI). This updated meta-analysis confirms succinylcholine

Area of Science:

  • Anesthesiology and Critical Care
  • Pharmacology and Therapeutics
  • Emergency Medicine

Background:

  • Emergency endotracheal intubation often requires rapid sequence induction (RSI) to prevent aspiration or manage intracranial pressure.
  • Succinylcholine is a common neuromuscular blocker for RSI due to its rapid onset and short duration, but carries risks.
  • Rocuronium is investigated as a potential alternative to succinylcholine for intubation procedures.

Purpose of the Study:

  • To compare the efficacy of rocuronium versus succinylcholine in achieving optimal intubating conditions during RSI.
  • To analyze intubating conditions based on rocuronium dosage, concurrent narcotic use, emergency vs. elective settings, patient age, and induction agents.
  • Primary outcome: excellent intubation conditions; Secondary outcome: acceptable intubation conditions.

Related Experiment Videos

Main Methods:

  • Updated systematic review and meta-analysis of randomized controlled trials and controlled clinical trials comparing rocuronium and succinylcholine.
  • Searched Cochrane Central Register, MEDLINE, and EMBASE databases, including foreign language journals and reference lists.
  • Data extracted independently by two authors; methodological quality assessed for allocation concealment; outcomes combined using random-effects model.

Main Results:

  • Meta-analysis of 37 studies (58 total identified) revealed succinylcholine superior to rocuronium (RR 0.86, 95% CI 0.80-0.92).
  • When propofol was used for induction, succinylcholine also yielded superior intubating conditions (RR 0.88, 95% CI 0.80-0.97).
  • No statistical difference in intubation conditions between succinylcholine and 1.2 mg/kg rocuronium, but succinylcholine's shorter duration is clinically advantageous.

Conclusions:

  • Succinylcholine demonstrated superior intubating conditions compared to rocuronium for both excellent and acceptable outcomes.
  • The findings contrast with previous analyses suggesting rocuronium superiority with propofol.
  • Succinylcholine remains the preferred agent due to its clinical profile, including duration of action.