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Related Experiment Videos

Interventions for treating collagenous colitis.

N Chande1, J W D McDonald, J K Macdonald

  • 1LHSC - South Street Hospital, Mailbox 55, 375 South Street, London, Ontario, Canada, N6A 4G5. nchande2@uwo.ca

The Cochrane Database of Systematic Reviews
|April 22, 2008
PubMed
Summary
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Budesonide effectively treats collagenous colitis, inducing and maintaining clinical and histological response. Evidence for bismuth subsalicylate and mesalamine is weak, while other therapies lack proven effectiveness in randomized trials.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Clinical Trials

Background:

  • Collagenous colitis is a chronic diarrhea cause.
  • Current treatments rely on limited evidence.
  • This review identifies therapies with randomized trial proof.

Purpose of the Study:

  • To determine effective treatments for collagenous colitis.
  • To evaluate therapies based on randomized controlled trials.

Main Methods:

  • Systematic literature search of MEDLINE, PubMed, and Cochrane databases (1970-2007).
  • Manual searches and conference abstracts reviewed for additional studies.
  • Ten randomized trials were identified and analyzed.

Main Results:

Related Experiment Videos

  • Budesonide showed significant clinical and histological response in active disease (P < 0.00001) and maintenance (P = 0.0002).
  • Bismuth subsalicylate demonstrated a 100% clinical response (P = 0.03).
  • Boswellia serrata extract, prednisolone, and probiotics showed no significant benefit compared to placebo.

    • Conclusions:

    • Budesonide is an effective treatment for inducing and maintaining collagenous colitis response.
    • Limited evidence supports bismuth subsalicylate and mesalamine.
    • Further research is needed for other investigated therapies.