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Related Experiment Video

Updated: Jul 5, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Interventions for alopecia areata.

F M Delamere¹, M M Sladden, H M Dobbins

¹Cochrane Skin Group, University of Nottingham, Centre of Evidence-Based Dermatology, Room A103, King's Meadow Campus, Lenton Lane, Nottingham, UK, NG7 2NR. finola.delamere@nottingham.ac.uk

The Cochrane Database of Systematic Reviews

|April 22, 2008

Summary

Current treatments for alopecia areata lack strong evidence of effectiveness. More large-scale studies are needed to assess long-term benefits and quality of life impacts for hair loss conditions.

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A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

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Published on: March 9, 2015

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Published on: January 27, 2018

Area of Science:

Dermatology
Clinical Trials
Hair Loss Disorders

Background:

Alopecia areata is a non-scarring hair loss condition affecting 0.15% of the population.
It can manifest as patchy hair loss (alopecia areata), total scalp hair loss (alopecia totalis), or complete body hair loss (alopecia universalis).
While often self-limiting, hair loss significantly impacts patients' social and emotional well-being.

Purpose of the Study:

To evaluate the efficacy of various interventions for managing alopecia areata, alopecia totalis, and alopecia universalis.
To synthesize findings from randomized controlled trials (RCTs) on alopecia treatments.

Main Methods:

Comprehensive literature search of multiple databases (Cochrane Skin Group, MEDLINE, EMBASE, etc.) up to February 2006.
Inclusion of randomized controlled trials assessing topical and systemic treatments for alopecia.
Data extraction and quality assessment by two independent reviewers, with contact to trial authors for additional information.

Main Results:

Seventeen trials involving 540 participants were analyzed, evaluating interventions like corticosteroids, ciclosporin, photodynamic therapy, and minoxidil.
No significant hair growth benefit was observed for any intervention compared to placebo.
No studies reported on patient-assessed hair growth or quality of life.

Conclusions:

Few alopecia areata treatments have been rigorously evaluated in RCTs.
Commonly used treatments such as corticosteroids and minoxidil lack convincing long-term efficacy data, despite appearing safe.
There is a critical need for large, well-conducted studies to assess long-term treatment effects on quality of life, considering spontaneous remission and alternative management options like wigs.