Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Treatment Resistent Cancers

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The variety and origin of materials accreted by Bennu's parent asteroid.

Nature astronomy·2025

Same author

Space weathering effects in Bennu asteroid samples.

Nature geoscience·2025

Same author

Mineralogical evidence for hydrothermal alteration of Bennu samples.

Nature geoscience·2025

Same author

An evaporite sequence from ancient brine recorded in Bennu samples.

Nature·2025

Same author

Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial β2 adrenergic receptors.

bioRxiv : the preprint server for biology·2023

Same author

Evaluating the potential of ChatGPT-4 in ophthalmology: The good, the bad and the ugly.

Journal francais d'ophtalmologie·2023

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Targeted therapy for advanced renal cell carcinoma.

C Coppin, L Le, F Porzsolt

The Cochrane Database of Systematic Reviews

|April 22, 2008

Summary

Targeted agents show promise in treating advanced renal cell carcinoma, offering improved survival and progression-free survival in specific patient groups. Further research is needed to fully establish their role in this resistant cancer.

Area of Science:

Oncology
Pharmacology

Background:

Advanced renal cell carcinoma (RCC) exhibits resistance to conventional therapies, necessitating novel treatment strategies.
Targeted agents offer a new approach by inhibiting key molecular pathways in cancer cell proliferation and tumor angiogenesis.
Clear cell RCC, characterized by high vascularity, is particularly responsive to anti-angiogenic therapies.

Purpose of the Study:

To systematically review studies evaluating targeted agents in advanced RCC.
To determine the clinical benefits of targeted agents compared to the standard of care, focusing on overall survival.

Main Methods:

Systematic review of randomized controlled trials identified through comprehensive database searches (CENTRAL, MEDLINE, EMBASE) and hand searches.
Studies included patients with advanced RCC reporting remission rates or overall survival.

More Related Videos

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Related Experiment Videos

Last Updated: Jul 5, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Progression-free survival (PFS) was also analyzed due to its common use as a primary outcome and crossover issues affecting overall survival data.

Main Results:

Temsirolimus demonstrated improved overall survival in systemically untreated patients with adverse prognostic features (median survival 10.9 vs 7.3 months).
Sunitinib and bevacizumab (in combination with interferon-alfa) improved progression-free survival and remission rates in specific patient subgroups with clear cell RCC.
Sorafenib improved quality of life and progression-free survival in patients with advanced RCC who had prior cytokine therapy.

Conclusions:

Targeted agents have shown clinically significant benefits over the previous standard of care for advanced RCC.
Specific agents like temsirolimus, sunitinib, bevacizumab, and sorafenib offer improved outcomes in different patient populations.
Further research is essential to fully elucidate the role and optimize the use of targeted agents in advanced RCC management.