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Endocannabinoids: some like it fat (and sweet too)
I Matias1, L Cristino, V Di Marzo
1U862 Centre de Recherche INSERM François Magendie, Université de Bordeaux, Bordeaux, France. isabelle.matias@bordeaux.inserm.fr
Journal of Neuroendocrinology
|May 9, 2008
Summary
The endocannabinoid system influences energy balance. Blocking cannabinoid receptor type 1 (CB1) may help treat obesity and metabolic syndrome by reducing food intake and fat storage.
Area of Science:
- Endocrinology
- Neuroscience
- Metabolic Research
Background:
- Growing interest in Rimonabant, a CB(1) receptor antagonist, for obesity and metabolic syndrome.
- CB(1) receptor blockers reduce food intake, abdominal adiposity, and metabolic issues.
- CB(1) receptors and endocannabinoids are present in key energy balance organs.
Purpose of the Study:
- To review the role of the endocannabinoid system in energy balance.
- To discuss the therapeutic potential of CB(1) receptor antagonists.
Main Methods:
- Review of clinical trial data on CB(1) receptor blockers.
- Analysis of the distribution and function of CB(1) receptors and endocannabinoids.
- Discussion of central and peripheral roles in energy homeostasis.
Main Results:
- CB(1) receptor antagonists show efficacy in reducing food intake and abdominal fat.
- The endocannabinoid system plays a dual role in central food intake regulation (hedonic and homeostatic).
- Peripherally, the endocannabinoid system appears to decrease energy expenditure and promote fat storage.
Conclusions:
- The endocannabinoid system is a significant regulator of energy balance.
- Targeting the CB(1) receptor presents a promising therapeutic strategy for obesity and metabolic syndrome.
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