Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Radiomics-based ultrasOund Model for differentiating Uterine Sarcomas from leiomyomas (ROMUS): a retrospective pilot Multicenter Italian Trials in Ovarian Cancer (MITO) study.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026

Same author

Cardiac delivery of modified mRNA using lipid nanoparticles: Cellular targets and biodistribution after intramyocardial administration.

Journal of controlled release : official journal of the Controlled Release Society·2024

Same author

Molecular mechanisms and targets of right ventricular fibrosis in pulmonary hypertension.

Pharmacology & therapeutics·2023

Same author

Preservation of human heart valves for replacement in children with heart valve disease: past, present and future.

Cell and tissue banking·2023

Same author

The Netherlands Heart Tissue Bank : Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2022

Same author

Electrocardiogram-based mortality prediction in patients with COVID-19 using machine learning.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2022

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

Stem cell sources for cardiac regeneration.

M Roccio¹, M J Goumans, J P G Sluijter

¹Laboratory of Experimental Cardiology, Division Heart & Lung, Department of Cardiology, University Medical Center, Utrecht, The Netherlands.

Panminerva Medica

|April 23, 2008

Summary

This summary is machine-generated.

Cell-based cardiac repair aims to regenerate heart muscle after myocardial infarction using various stem cells. Bone marrow cells and cardiac precursors show promise over embryonic stem cells for regenerative therapy.

More Related Videos

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

Published on: January 7, 2019

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Published on: January 12, 2015

Related Experiment Videos

Last Updated: Jul 5, 2026

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

Published on: January 7, 2019

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Published on: January 12, 2015

Area of Science:

Regenerative Medicine
Cardiovascular Research
Stem Cell Biology

Background:

Myocardial infarction (MI) causes significant loss of cardiac muscle, impairing heart function.
Cell-based therapies aim to replace damaged cardiomyocytes and restore cardiac contractility.
Various stem cell types, including embryonic stem cells (ESCs), have been investigated for cardiac repair.

Purpose of the Study:

To review current knowledge on different cell types for cardiac regeneration.
To evaluate the potential of various stem cells in treating myocardial infarction.
To discuss challenges and future directions in cell-based cardiac repair.

Main Methods:

Review of existing literature on stem cell populations for cardiac repair.
Analysis of cell differentiation capabilities into cardiomyocytes and vascular lineages.
Assessment of immunogenicity, tumorigenicity, and ethical considerations of different cell sources.

Main Results:

Embryonic stem cells (ESCs) demonstrate differentiation into cardiac and vascular cells but pose risks (immunogenicity, tumor development, ethics).
Bone marrow-derived cells and cardiac progenitor cells offer potential alternatives, overcoming ethical and allogeneic issues.
Understanding stem cell differentiation is crucial for effective cardiac regeneration.

Conclusions:

Bone marrow-derived cells and cardiac precursors are more suitable for regenerative therapy than ESCs due to safety and ethical advantages.
Further research is needed on cell delivery methods and tissue engineering for successful cardiac repair.
Cell-based cardiac regeneration holds significant promise for treating heart damage post-MI.