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Updated: Jul 5, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Manipulation of androgens and alterations in the androgen receptor axis in prostate cancer

M M Nguyen1, Z Wang

  • 1University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology
|April 23, 2008
PubMed

Insights

Androgen deprivation therapy (ADT) is a primary prostate cancer (PCa) treatment, but resistance develops. This review explores changes in the androgen receptor (AR) axis driving treatment resistance and advances in ADT.

Area of Science:

  • Oncology
  • Urology
  • Molecular Biology

Background:

  • Androgens are crucial in prostate cancer (PCa) development and progression.
  • Androgen deprivation therapy (ADT) is the standard treatment for metastatic PCa.
  • Prostate tumors often become resistant to ADT, leading to disease recurrence.

Purpose of the Study:

  • To review alterations in the androgen receptor (AR) signaling axis in treatment-resistant prostate cancer.
  • To highlight recent advancements in androgen deprivation therapy for prostate cancer.

Main Methods:

  • Literature review of studies on androgen receptor function in prostate cancer.
  • Analysis of molecular changes associated with treatment resistance.
  • Examination of emerging therapeutic strategies for advanced prostate cancer.

Main Results:

  • AR gene amplification, mutations, and altered localization contribute to treatment resistance.
  • Upregulation of AR activity is a common mechanism in refractory prostate cancers.
  • Recent advances in ADT offer new therapeutic avenues.

Conclusions:

  • Understanding AR axis changes is vital for overcoming treatment resistance in PCa.
  • Targeting the AR pathway holds promise for improved prostate cancer therapies.
  • Further research into AR biology will guide the development of novel treatment strategies.

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