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Related Experiment Video

Updated: Jul 5, 2026

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
10:18

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

Published on: May 6, 2018

Gene transfer to arteries.

Levent M Akyürek1, Hong San, Elizabeth G Nabel

  • 1National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA.

Current Protocols in Human Genetics
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

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This study details methods for delivering genes to arteries in animal models. These protocols cover normal, injured, and atherosclerotic arteries for research and therapeutic applications.

Area of Science:

  • Vascular biology
  • Gene therapy
  • Animal models

Background:

  • Gene therapy offers potential for treating vascular diseases.
  • Effective delivery of genetic material to arteries is crucial for therapeutic success.
  • Existing methods require refinement for diverse arterial conditions.

Purpose of the Study:

  • To establish comprehensive protocols for arterial gene delivery.
  • To adapt gene delivery methods for normal, injured, and atherosclerotic arteries.
  • To provide standardized techniques for preclinical research.

Main Methods:

  • Detailed protocols for animal preparation, surgical techniques, and vector delivery systems.
  • Gene delivery to porcine iliofemoral arteries using a double balloon infusion catheter.

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Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique
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Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique

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Related Experiment Videos

Last Updated: Jul 5, 2026

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
10:18

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

Published on: May 6, 2018

A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts
13:58

A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts

Published on: September 10, 2018

Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique
07:13

Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique

Published on: May 2, 2025

  • Gene delivery to rabbit atherosclerotic arteries via surgical exposure and catheter instillation.
  • Gene delivery to murine carotid and femoral arteries.
  • Percutaneous gene delivery methods.

    • Main Results:

    • Successful implementation of gene delivery protocols across various animal models and arterial states.
    • Demonstration of catheter-based delivery in normal, injured, stented, and atherosclerotic arteries.
    • Adaptability of protocols for both injured and non-injured atherosclerotic vessels.

    Conclusions:

    • The provided protocols offer a robust framework for arterial gene delivery research.
    • These methods facilitate the study of gene function in vascular health and disease.
    • The protocols support the development of novel gene-based therapies for vascular conditions.