Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of the functional and structural characteristics of rare TSC2 variants with clinical and genetic findings.

Human mutation·2019

Same author

Rare single gene disorders: estimating baseline prevalence and outcomes worldwide.

Journal of community genetics·2018

Same author

Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure.

Journal of the American Society of Nephrology : JASN·2018

Same author

Molecular genetics research in sub-Saharan Africa: how can the international community help?

The HUGO journal·2016

Same author

Persistent severe polyuria after renal transplant.

Clinical kidney journal·2016

Same author

Variants Within TSC2 Exons 25 and 31 Are Very Unlikely to Cause Clinically Diagnosable Tuberous Sclerosis.

Human mutation·2015

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Human and mouse gene nomenclature.

Hester Wain¹, Sue Povey, Lois Maltais

¹University College London, London, United Kingdom.

Current Protocols in Human Genetics

|April 23, 2008

Summary

Standard genetic nomenclature provides a universal language for gene symbols, essential for researchers and the public. This system ensures clear communication and data access for both human and mouse genes.

Area of Science:

Genetics
Bioinformatics
Scientific Communication

Background:

Standardized gene nomenclature is crucial for accessing genetic data and facilitating global scientific communication.
Each gene in humans and mice is assigned a unique symbol and name.
Coordination between human and mouse gene nomenclature has been historically successful.

Purpose of the Study:

To discuss the development and organization of gene nomenclature systems.
To provide guidance on how to locate specific genes.
To outline the process for naming new genes.

Main Methods:

Review of historical development of gene nomenclature.
Description of organizational structures of nomenclature committees.

More Related Videos

Mouse Genome Engineering Using Designer Nucleases

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Related Experiment Videos

Last Updated: Jul 5, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Mouse Genome Engineering Using Designer Nucleases

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Explanation of procedures for gene identification and naming.

Main Results:

Established a framework for understanding gene nomenclature.
Highlighted the importance of coordinated human and mouse gene naming.
Provided practical information for researchers on gene identification and naming.

Conclusions:

Standardized gene nomenclature is vital for scientific progress and data accessibility.
Effective organization and historical collaboration underpin successful gene nomenclature.
Clear guidelines are essential for naming new genes and facilitating research.