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Related Concept Videos

ER Retrieval Pathway01:45

ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Searching the NCBI databases using Entrez.

Andreas D Baxevanis

    Current Protocols in Human Genetics
    |April 23, 2008
    PubMed
    Summary
    This summary is machine-generated.

    The NCBI Entrez system efficiently retrieves biological information by leveraging natural links between database entries. This guide details text-based searches and advanced features for comprehensive data exploration.

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    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Information Retrieval

    Background:

    • Biological databases contain vast amounts of interconnected information.
    • Accessing comprehensive data on biological entities often requires querying multiple disparate databases.
    • The need for an integrated approach to biological data retrieval is critical.

    Purpose of the Study:

    • To introduce the NCBI Entrez system as a unified interface for biological information retrieval.
    • To demonstrate methods for accessing and exploring data linked within Entrez.
    • To provide practical guidance on utilizing Entrez features for efficient data discovery.

    Main Methods:

    • Description of basic, text-based search protocols within the Entrez system.
    • Illustration of how Entrez utilizes pre-existing biological relationships between database entries.
    • Explanation of an alternate protocol using advanced Entrez features for query refinement.
    • Review of a support protocol for saving frequently used queries.

    Main Results:

    • Entrez enables efficient retrieval of information by exploiting inherent biological connections.
    • Basic and alternate protocols demonstrate effective data discovery through text-based and advanced queries.
    • The system facilitates a holistic view of biological entities by linking disparate data.

    Conclusions:

    • The NCBI Entrez system provides a powerful, integrated platform for biological data exploration.
    • Understanding Entrez search functionalities enhances the ability to retrieve comprehensive biological information.
    • Tools like Cn3D further support the visualization and analysis of retrieved biological data.