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Related Experiment Video

Updated: Jul 5, 2026

Methods for Intravenous Self Administration in a Mouse Model
12:09

Methods for Intravenous Self Administration in a Mouse Model

Published on: December 8, 2012

Intravenous self-administration techniques in monkeys.

Donna M Platt1, Galen Carey, Roger D Spealman

  • 1New England Primate Research Center Harvard Medical School, Southborough, Massachusetts, USA.

Current Protocols in Neuroscience
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

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Primates model human drug-taking behavior through drug self-administration, aiding research into addiction treatments and drug abuse potential. This method helps study drug reinforcement processes.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Drug self-administration is a key operant behavior where subjects trigger drug delivery via responses.
  • This procedure is a valuable model for understanding human drug-taking behaviors.
  • Primate models, particularly monkeys, exhibit drug-taking patterns similar to humans.

Purpose of the Study:

  • To describe intravenous drug self-administration procedures in primates.
  • To highlight the utility of these procedures in studying drug abuse potential.
  • To investigate the mechanisms of drug reinforcement and evaluate addiction treatments.

Main Methods:

  • Intravenous drug self-administration in large primates (e.g., rhesus macaques).
  • Intravenous drug self-administration in smaller primates (e.g., squirrel monkeys).

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Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice
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Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain
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Related Experiment Videos

Last Updated: Jul 5, 2026

Methods for Intravenous Self Administration in a Mouse Model
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Methods for Intravenous Self Administration in a Mouse Model

Published on: December 8, 2012

Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice
05:55

Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice

Published on: October 3, 2011

Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain
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  • Operant conditioning techniques to establish drug-seeking and drug-taking behaviors.

    • Main Results:

    • Commonly abused human drugs maintain self-administration in monkeys.
    • Drug self-administration procedures effectively model human drug-taking behavior.
    • These methods allow for the assessment of abuse liability and treatment efficacy.

    Conclusions:

    • Primate drug self-administration is a robust model for human drug use.
    • This methodology is crucial for evaluating novel compounds and addiction therapies.
    • Understanding drug reinforcement processes is facilitated by these experimental models.