Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RNA folding pathways.

D M Crothers1

  • 1Yale University, New Haven, Connecticut, USA.

Current Protocols in Nucleic Acid Chemistry
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

This study explores RNA folding challenges, differentiating them from protein folding. It covers structure determination, folding dynamics, and conformational changes in ribonucleic acid.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Climate change and the integrity of science.

Science (New York, N.Y.)·2010
Same author

Comparison of analyses of DNA curvature.

Journal of biomolecular structure & dynamics·2003
Same author

High-resolution transcription assay for probing drug-DNA interactions at individual drug sites.

Methods in enzymology·2001
Same author

Simultaneous measurement of binding constants and unwinding angles by gel electrophoresis.

Methods in enzymology·2001
Same author

Kinetic consequences of covalent linkage of DNA binding polyamides.

Biochemistry·2001
Same author

Global structure and mechanical properties of a 10-bp nucleosome positioning motif.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same journal

Synthesis of Unmodified Oligonucleotides.

Current protocols in nucleic acid chemistry·2022
Same journal

Biophysical Analysis of Nucleic Acids.

Current protocols in nucleic acid chemistry·2022
Same journal

RNA Folding Pathways.

Current protocols in nucleic acid chemistry·2022
Same journal

Nucleic Acid Binding Molecules.

Current protocols in nucleic acid chemistry·2022
Same journal

Biologically Active Nucleosides.

Current protocols in nucleic acid chemistry·2020
Same journal

Biologically Active Nucleosides.

Current protocols in nucleic acid chemistry·2020
See all related articles

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Ribonucleic acid (RNA) folding is crucial for its biological functions.
  • Understanding RNA folding mechanisms is complex due to its unique properties compared to proteins.

Purpose of the Study:

  • To provide a comprehensive overview of the key questions and challenges in RNA folding.
  • To highlight the distinctions between RNA and protein folding problems.

Main Methods:

  • Comparative analysis of RNA and protein folding principles.
  • Review of methodologies for determining RNA structures.
  • Discussion of kinetic and thermodynamic aspects of RNA folding/unfolding.

Main Results:

Related Experiment Videos

  • RNA folding presents distinct challenges compared to protein folding.
  • Various methods exist for RNA structure determination.
  • The dynamics of folding, unfolding, and conformational switching are critical aspects.

    • Conclusions:

    • Addressing RNA folding requires specialized approaches.
    • Further research into the spatial and temporal resolution of folding processes is needed.
    • Conformational flexibility and switching are key features of RNA function.