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Related Concept Videos

Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Folding01:22

Protein Folding

Overview

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Related Experiment Video

Updated: Jul 5, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein tertiary structure modeling.

Nicolas Guex1, Torsten Schwede1, Manuel C Peitsch1

  • 1Glaxo Wellcome Experimental Research, Geneva, Switzerland.

Current Protocols in Protein Science
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

Comparative protein modeling offers a practical alternative when experimental protein structures are unavailable. This method utilizes sophisticated, free software to aid in experiment design.

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Last Updated: Jul 5, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

3D Printing of Biomolecular Models for Research and Pedagogy
09:17

3D Printing of Biomolecular Models for Research and Pedagogy

Published on: March 13, 2017

Area of Science:

  • Structural biology
  • Computational biology
  • Biochemistry

Background:

  • Understanding protein 3D-structure is crucial for experimental design.
  • Experimental structure determination is not always feasible.
  • Comparative protein modeling serves as a valuable alternative.

Purpose of the Study:

  • To present the principles of comparative protein modeling.
  • To guide users on employing free, sophisticated, and user-friendly software for protein modeling.

Main Methods:

  • Comparative protein modeling techniques.
  • Utilizing free online software for structural modeling.

Main Results:

  • Demonstration of a viable approach for obtaining protein 3D-structures.
  • Highlighting the accessibility of advanced modeling tools.

Conclusions:

  • Comparative protein modeling is an effective strategy when experimental data is lacking.
  • Free software makes advanced protein structure prediction accessible for research.