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Peptide Bonds

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

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Updated: Jul 5, 2026

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Published on: May 15, 2012

Guide for resin and linker selection in solid-phase peptide synthesis.

¹The Scripps Research Institute, La Jolla, California, USA.

Current Protocols in Protein Science

|April 23, 2008

Summary

This summary is machine-generated.

This guide simplifies solid-phase peptide synthesis (SPPS) by explaining linker and resin chemistry. It details common materials and provides protocols for preparing functionalized resins for peptide synthesis.

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Last Updated: Jul 5, 2026

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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

Area of Science:

Organic Chemistry
Biochemistry
Synthetic Chemistry

Background:

Solid-phase peptide synthesis (SPPS) relies heavily on diverse linkers and resins.
A lack of clarity exists regarding the selection and application of these critical SPPS components.
Understanding chemical principles is essential for effective SPPS.

Purpose of the Study:

To clarify the selection of linkers and resins in solid-phase peptide synthesis.
To provide a foundational understanding of the chemical principles governing linker and resin behavior.
To offer practical guidance for SPPS practitioners.

Main Methods:

Detailed presentation and description of commonly used linkers and resins.
Explanation of the development history and common applications of SPPS materials.
Inclusion of key protocols for preparing linker-functionalized resins.

Main Results:

A comprehensive overview of prevalent linkers and resins in SPPS.
Insights into the chemical trends and practical considerations for material selection.
Protocols enabling the preparation of customized resins for various peptide synthesis needs.

Conclusions:

Demystification of the complex landscape of SPPS linkers and resins.
Empowerment of both novice and experienced researchers with fundamental knowledge.
Facilitation of efficient and successful peptide synthesis through informed material choice.