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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Folding01:22

Protein Folding

Overview

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Updated: Jul 5, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Protein structure analysis online.

Maria A Miteva1, Emil Alexov, Bruno O Villoutreix

  • 1Inserm U648, University of Paris, Paris, France.

Current Protocols in Protein Science
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

Online computational biology tools aid life science research but can be complex. This unit reviews accessible online methods for protein structure, function, and drug discovery, simplifying complex analyses for researchers.

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

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Related Experiment Videos

Last Updated: Jul 5, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Area of Science:

  • Computational biology and chemistry
  • Life and health sciences research

Background:

  • Computational tools are integral to modern life and health sciences.
  • Rapid development of these methods presents challenges for researchers of all levels.
  • Recent years have seen a surge in online computational packages to address these challenges.

Purpose of the Study:

  • To provide an overview of online computational methods for life and health sciences.
  • To focus on practical applications and facilitate the use of complex tools.
  • To highlight resources for structural refinement, simulations, and molecular interactions.

Main Methods:

  • Review of recently implemented online computational packages.
  • Emphasis on specific applications: structural refinement, atomic simulations, electrostatic calculations.
  • Exploration of functional site and druggable pocket identification, protein and small molecule docking.
  • Inclusion of methods for predicting amino acid variation impact on protein structure and function.

Main Results:

  • Identification of key online computational tools across various research areas.
  • Demonstration of the utility of these tools for complex analyses.
  • Facilitation of research in protein structure-function relationships and drug discovery.

Conclusions:

  • Online computational methods are increasingly vital and accessible for life/health science research.
  • These tools simplify complex analyses like protein docking and variation impact prediction.
  • Researchers can leverage these resources to advance structural biology and drug development.