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Clinical and histopathologic study of pilomatricoma in Iran between 1992 and 2005
Abbas Zamanian1, Mahmood Farshchian, Mehdi Farshchian
1Department of Dermatology, Sina Hospital, Hamedan University of Medical Sciences, Hamedan, Iran.
Abstract:
Pilomatricoma (calcifying epithelioma of Malherb) is a tumor of hair follicle matrix cells and is almost always benign. In this study we reviewed the clinical and histopathological features of 45 cases of pilomatricoma during 13 years (1992-2005). Although few malignant transformations have been reported in other studies, no evidence of malignancy or aggressiveness is observed in this study.
Insights
Pilomatricoma, a benign hair follicle tumor, was studied in 45 cases. This review found no evidence of malignancy or aggressive behavior in the examined pilomatricoma cases.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Pilomatricoma, also known as calcifying epithelioma of Malherb, originates from hair follicle matrix cells.
- This tumor is predominantly benign, with rare reports of malignant transformation in existing literature.
Purpose of the Study:
- To review the clinical and histopathological features of pilomatricoma.
- To assess the potential for malignancy or aggressiveness in a series of pilomatricoma cases.
Main Methods:
- Retrospective review of 45 pilomatricoma cases.
- Analysis of clinical presentation and histopathological findings.
- Data collected over a 13-year period (1992-2005).
Main Results:
- The study analyzed 45 cases of pilomatricoma.
- Histopathological examination revealed no signs of malignancy.
- No evidence of aggressive tumor behavior was observed in this cohort.
Conclusions:
- Pilomatricoma is consistently a benign neoplasm.
- The findings support the generally accepted benign nature of pilomatricoma.
- Further long-term studies may be warranted to confirm the absence of late malignant transformation.