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[Correlation between hypercholesterolemia and vitamin C deficient diet].

I Fujimura1, S M Geraldes, L S Ito

  • 1Departamento de Anatomia, Faculdade de Medicina de Jundiaí.

Revista Do Hospital Das Clinicas
|January 1, 1991
PubMed
Summary

Low ascorbic acid (vitamin C) intake is linked to higher cholesterol levels and increased risk of hypercholesterolemia. Dietary vitamin C deficiency may contribute to cholesterol imbalance and varicosity, indicating poor vitamin C status.

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Area of Science:

  • Biochemistry
  • Nutrition Science
  • Cardiovascular Health

Background:

  • Ascorbic acid (vitamin C) deficiency impacts lecithin cholesterol acyl-transferase activity and cholesterol transformation into biliary acids.
  • Sublingual vein varicosity is a clinical indicator of hypovitaminosis C.

Purpose of the Study:

  • To compare dietary ascorbic acid intake in patients with normal cholesterol versus hypercholesterolemia.
  • To investigate the association between cholesterol levels, ascorbic acid intake, and sublingual vein varicosity.

Main Methods:

  • Comparative study of 30 patients (15 normal cholesterol, 15 hypercholesterolemia).
  • Assessment of dietary ascorbic acid and cholesterol intake.
  • Clinical examination for sublingual vein varicosity.

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  • Statistical analysis using "t" Student and Control-Case tests.

    • Main Results:

    • Significant difference in cholesterol levels between hypercholesterolemia (422 +/- 116.2 mg/100 ml) and normal (160.7 +/- 29.5 mg/100 ml) groups.
    • Higher ascorbic acid intake observed in the normal cholesterol group compared to the hypercholesterolemia group.
    • Sublingual vein varicosity was significantly more frequent (p < 0.0001) in hypercholesterolemia patients with lower ascorbic acid intake.

    Conclusions:

    • Dietary ascorbic acid intake is significantly lower in hypercholesterolemia patients.
    • Hypovitaminosis C, indicated by sublingual vein varicosity, is more prevalent in hypercholesterolemia.
    • Ascorbic acid deficiency may play a role in cholesterol metabolism and hypercholesterolemia development.