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Osteosclerotic myeloma.

A R Rodriguez, C L Lutcher, F W Coleman

    JAMA
    |October 18, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Osteosclerotic myeloma, a rare variant, presents with unusual symptoms like peripheral neuropathy and lymphadenopathy. These clinical features, alongside elevated alkaline phosphatase and cerebrospinal fluid immunoglobulin, distinguish it from classical myeloma.

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    Area of Science:

    • Hematology
    • Neurology
    • Oncology

    Background:

    • Multiple myeloma is a malignant plasma cell disorder.
    • Classical myeloma typically presents with bone lesions, anemia, renal failure, and hypercalcemia.
    • Osteosclerotic myeloma is a rare subtype with distinct clinical and biological features.

    Observation:

    • A 49-year-old male patient presented with an osteosclerotic lesion in a thoracic vertebra.
    • The patient exhibited peripheral neuropathy and lymphadenopathy.
    • Elevated serum alkaline phosphatase and monoclonal immunoglobulin in cerebrospinal fluid were noted.

    Findings:

    • The observed combination of symptoms (osteosclerotic lesion, neuropathy, lymphadenopathy, elevated alkaline phosphatase, and CSF monoclonal immunoglobulin) is atypical for classical myeloma.

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  • These findings are consistent with the osteosclerotic variant of myeloma.
  • The osteosclerotic form of myeloma can manifest with a unique constellation of clinical and laboratory abnormalities.

    • Implications:

    • Recognition of these atypical features is crucial for diagnosing osteosclerotic myeloma.
    • This case highlights the importance of considering rare myeloma variants in patients with unusual presentations.
    • Further research into the pathogenesis and treatment of osteosclerotic myeloma is warranted.