[Polimorphonuclear leukocytes and diabetes mellitus]

Related Experiment Video

Updated: Jul 5, 2026

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature
05:54

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature

Published on: January 24, 2025

E Hopps1, A Camera, G Caimi

  • 1Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Cattedra di Semeiotica e Metodologia Medica, Università di Palermo, Palermo, Italy. euhopps@libero.it

Minerva Medica
|April 24, 2008
PubMed

Insights

Diabetic patients experience increased infection risk due to impaired polymorphonuclear leukocytes (PMN) function. Hyperglycemia and related conditions disrupt PMN

Area of Science:

  • Immunology
  • Endocrinology
  • Cell Biology

Context:

  • Diabetic individuals exhibit heightened susceptibility to infections, characterized by increased frequency and severity.
  • Underlying factors include hyperglycemia, microangiopathy, and a compromised immune system.
  • Specific immune cell dysfunction involves polymorphonuclear leukocytes (PMN).

Purpose:

  • To investigate the functional alterations in polymorphonuclear leukocytes (PMN) of diabetic patients.
  • To explore the relationship between glycemic control and PMN functional parameters.
  • To examine the impact of hyperglycemia on PMN surface receptors and interactions.

Summary:

  • Diabetic patients present with polymorphonuclear leukocyte (PMN) dysfunction, affecting chemotaxis, phagocytosis, and bacterial killing.
  • Parameters such as bacterial phagocytosis, oxidative burst chemiluminescence, and cell deformability correlate with glycemic levels and HbA1c.
  • Altered integrin expression and surface receptor abnormalities on diabetic PMNs, linked to cytoskeletal and signal transduction defects, may impair endothelial cell interactions and diapedesis.

Impact:

  • Understanding PMN dysfunction in diabetes can lead to targeted strategies for infection prevention.
  • This research highlights the critical role of glycemic control in maintaining immune competence.
  • Findings may inform the development of novel therapeutic approaches to mitigate infection risk in diabetic populations.

More Related Videos

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...