Related Experiment Video
Updated: Jul 5, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Technology insight: metabonomics in gastroenterology-basic principles and potential clinical applications
Jacob T Bjerrum1, Ole H Nielsen, Yulan L Wang
1Unit of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Denmark. jacbje01@heh.regionh.dk
Metabonomics, the study of metabolic changes, offers a systems-biology approach. This field, using techniques like nuclear magnetic resonance spectroscopy, aids in disease diagnosis and biomarker discovery.
Area of Science:
- Systems Biology
- Metabolomics
- Biomarker Discovery
Background:
- Metabonomics is an emerging field studying metabolic changes in biological systems.
- It complements genomics, transcriptomics, and proteomics for a holistic systems-biology approach.
- Nuclear magnetic resonance spectroscopy is a key technology in metabonomics.
Purpose of the Study:
- To introduce the principles of nuclear magnetic resonance spectroscopy and data analysis tools.
- To review the applications and future potential of metabonomics in research.
- To emphasize metabonomics applications in gastroenterology.
Main Methods:
- Principles of nuclear magnetic resonance (NMR) spectroscopy.
- Multivariate data analysis techniques.
- Review of existing literature on metabonomics applications.
Main Results:
- Metabonomics aids in identifying biomarkers and prognostic factors.
- It has potential to enhance clinical diagnosis and hypothesis generation.
- Successful applications demonstrated in human diseases, toxicology, microbes, nutrition, and plant biology.
Conclusions:
- Metabonomics provides a comprehensive approach to understanding in vivo function.
- The field has broad applications in basic and clinical research, particularly gastroenterology.
- Future potential lies in advancing diagnostic and research capabilities.
Related Concept Videos
What is Monogastric Digestion?
MALDI-TOF Mass Spectrometry
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
Serum Laboratory Studies, Stool Test, Breath Test

