Related Experiment Video

Updated: Jul 5, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

[Long-term observation of children with gastro-esophageal reflux disease]

Izabela Jastrzebska1, Krzysztof Fyderek

  • 1Klinika Pediatrii, Gastroenterologii i Zywienia, Uniwersytet Jagielloński Collegium Medicum w Krakowie. dobosz@mp.pl

Przeglad Lekarski
|April 25, 2008
PubMed

Insights

Gastroesophageal reflux disease (GERD) in children over one year old rarely resolves completely. Acid reflux can persist even without noticeable symptoms, indicating a chronic condition.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Disorders
  • Clinical Research

Context:

  • Gastroesophageal reflux disease (GERD) is common in children, often viewed as transient.
  • Understanding GERD's natural history in pediatric populations is crucial for effective management.
  • This study investigates the long-term outcomes of GERD in infants and children.

Purpose:

  • To assess the natural history and long-term symptom resolution of GERD in pediatric patients.
  • To evaluate the persistence of acid reflux in children diagnosed with GERD.
  • To compare GERD outcomes across different age groups in children.

Summary:

  • A cohort of 163 children diagnosed with GERD underwent follow-up after 3.5 years.
  • Symptom resolution rates were significantly higher in infants under 1 year (45%) compared to older children (13.4-14.3%).
  • Pathologic acid reflux persisted in 54% of patients, including asymptomatic cases, highlighting the chronic nature of GERD in older children.

Impact:

  • GERD symptoms are unlikely to resolve completely in children over one year of age.
  • Subclinical acid reflux may persist in pediatric GERD patients.
  • Findings suggest GERD may be a more chronic condition in children than previously assumed, necessitating ongoing monitoring.
Abstract

More Related Videos

Surgical Models of Gastroesophageal Reflux with Mice05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

Related Concept Videos

Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...