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Related Concept Videos

Ascites01:19

Ascites

DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...
Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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Related Experiment Video

Updated: Jul 5, 2026

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
07:17

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

[Myelomatous ascites].

P Young1, B B Finn, D Pellegrini

  • 1Departamento de Medicina Interna, Hospital Británico de Buenos Aires, Argentina. pabloyoung2003@yahoo.com.ar

Anales De Medicina Interna (Madrid, Spain : 1984)
|April 25, 2008
PubMed
Summary
This summary is machine-generated.

Ascites in multiple myeloma (MM) is rare and often linked to poor prognosis. This study details the first reported case of myelomatous ascites in a patient with plasma cell leukemia, highlighting mixed causes.

Related Experiment Videos

Last Updated: Jul 5, 2026

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
07:17

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

Area of Science:

  • Hematology
  • Oncology
  • Gastroenterology

Background:

  • Ascites is an uncommon complication in multiple myeloma (MM).
  • Common causes include increased peritoneal permeability or portal hypertension from liver infiltration.
  • Myelomatous ascites is more frequent in patients with Ig-G or Ig-A paraproteins and carries a poor prognosis.

Observation:

  • A 50-year-old female patient with IgA-kappa MM presented with cardiac failure (CF), plasma cell leukemia, and ascites.
  • The ascites was of mixed etiology, stemming from peritoneal myelomatous cell infiltration, hepatic compromise, and CF.
  • This represents the first documented case of myelomatous ascites in a patient with plasma cell leukemia.

Findings:

  • The patient's ascites was attributed to a combination of factors: direct peritoneal involvement by myeloma cells, liver dysfunction, and cardiac failure.
  • A comprehensive review of the literature on myelomatous ascites in MM patients was conducted.
  • This case expands the known clinical presentations of MM-associated ascites.

Implications:

  • This case highlights the complex and multifactorial nature of ascites in advanced multiple myeloma.
  • Early recognition and management of ascites in MM, particularly in the context of plasma cell leukemia, are crucial.
  • Further research is warranted to understand the specific mechanisms and improve outcomes for MM patients with ascites.