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Adjuvant arthritis in the rat.

Willem van Eden¹, Josee P A Wagenaar-Hilbers¹, Marca H M Wauben¹

¹Institute of Infectious Diseases and Immunology, Utrecht, The Netherlands.

Current Protocols in Immunology

|April 25, 2008

Summary

Adjuvant arthritis (AA) is a T cell-mediated autoimmune condition in rats, often used to model human rheumatoid arthritis and test anti-inflammatory drugs. This study details the induction, evaluation, and adjuvant preparation for AA research.

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Area of Science:

Immunology
Rheumatology
Pharmacology

Background:

Adjuvant arthritis (AA) is a T cell-mediated autoimmune disease in rats, serving as a model for human rheumatoid arthritis (RA).
Genetic susceptibility varies among rat strains, with mice generally being non-susceptible.
AA is induced using mycobacteria in oil or oily adjuvants, mimicking aspects of spontaneous human arthritic diseases.

Purpose of the Study:

To describe the induction and evaluation methods for Adjuvant Arthritis (AA) in susceptible rat strains.
To detail the preparation of adjuvants used in AA induction.
To provide a timeline for AA development.

Main Methods:

Induction of AA in susceptible rat strains using specific adjuvants.
Evaluation of AA development and severity.
Preparation of the oily adjuvant for AA induction.

Main Results:

AA is a self-remitting inflammatory process in susceptible rats, despite potential for severe joint malformations and ankylosis.
The study outlines a timeline for AA progression.
Methods for AA induction and evaluation are presented.

Conclusions:

Adjuvant arthritis is a valuable T cell-mediated model for studying RA immunology and testing anti-inflammatory drugs.
The described methods facilitate reproducible AA induction and evaluation.
Understanding AA's timeline and inflammatory process aids in developing therapeutic strategies.

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