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Candidiasis

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Updated: Jul 5, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

Animal models for candidiasis.

¹University of Perugia, Perugia, Italy.

Current Protocols in Immunology

|April 25, 2008

Summary

This summary is machine-generated.

This study outlines experimental methods for developing Candida albicans infections in mice and rats. It details procedures for studying yeast/host interactions and detecting fungal growth.

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Last Updated: Jul 5, 2026

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Published on: November 17, 2018

Area of Science:

Microbiology
Immunology
Infectious Diseases

Background:

Limited understanding of yeast/host interactions in Candida species beyond C. albicans.
Need for standardized experimental models to study fungal pathogenesis.

Purpose of the Study:

To provide detailed materials and methods for establishing experimental Candida albicans infections in animal models.
To facilitate research on yeast/host interactions in various infection types.

Main Methods:

Development of gastrointestinal and disseminated infections in infant Swiss White mice.
Induction of disseminated infections in immunocompromised adult BALB/c mice.
Establishment of primary acute disseminated infections in BALB/c and DBA/2 mice.
Creation of vaginal infections in CBA/J mice and Wistar rats.
Detailed protocols for Candida albicans cultivation and detection.

Main Results:

Successfully established diverse experimental Candida albicans infection models.
Provided comprehensive methods for fungal growth and detection.

Conclusions:

The described methods enable robust investigation of Candida albicans pathogenesis and host responses.
These protocols support comparative studies of yeast/host interactions across different infection models.