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Related Experiment Video

Updated: Jul 5, 2026

Murine Skin Transplantation

Murine Skin Transplantation

Published on: January 16, 2008

Skin allograft rejection.

Amy S Rosenberg¹

¹Food and Drug Administration, Bethesda, Maryland.

Current Protocols in Immunology

|April 25, 2008

Summary

This summary is machine-generated.

Tail-skin grafts are easy to perform and assess T lymphocyte competence for antiviral and tumor immunity. However, trunk-skin grafts are more sensitive for detecting minor histocompatibility differences.

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Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

Area of Science:

Immunology
Transplantation Biology

Background:

Skin allograft rejection models are crucial for evaluating T lymphocyte-mediated immunity.
Assessing T cell competence is vital for understanding anti-viral and anti-tumor responses.

Purpose of the Study:

To describe and compare tail-skin and trunk-skin grafting procedures in mice.
To delineate the applications and limitations of each grafting method for immunological studies.

Main Methods:

Detailed description of the tail-skin grafting technique, emphasizing ease of preparation and resistance to necrosis.
Detailed description of the trunk-skin grafting technique, noting increased complexity and susceptibility to necrosis.
Comparison of the sensitivity of tail and trunk skin in detecting histocompatibility differences.

Main Results:

Tail-skin grafts offer a practical method for assessing T lymphocyte competence without donor sacrifice.
Tail-skin grafts are less sensitive than trunk-skin grafts for detecting minor histocompatibility antigens.
Trunk-skin grafts, despite technical challenges, are superior for identifying minimal histocompatibility disparities.

Conclusions:

Tail-skin grafts are suitable for general T cell function assessment but not for minor antigen detection.
Trunk-skin grafts are the preferred method for studies requiring high sensitivity to detect minor histocompatibility differences.
These distinct grafting models provide valuable tools for specific immunological research questions.