Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Obstructive Pulmonary Disease II: Emphysema

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...

Pneumothorax-II

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cystic Fibrosis-Related Bone Disease in Youth: High-Risk Population With Low Screening Adherence.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026

Same author

Corrigendum to 'Brief parent-report measure of slowness in eating is associated with weight status in children with cystic fibrosis over a 3-year follow-up', Physiology & Behavior 2025 115104.

Physiology & behavior·2026

Same author

Brief parent-report measure of slowness in eating is associated with weight status in children with cystic fibrosis over a 3-year follow-up.

Physiology & behavior·2025

Same author

Respiratory Morbidity Among Children Undergoing Surgical Resection for a Congenital Lung Malformation.

Pediatric pulmonology·2024

Same author

Feasibility of Using Continuous Glucose Monitoring to Detect Glycemic Abnormalities in Children with Cystic Fibrosis.

Hormone research in paediatrics·2024

Same author

Parental perceptions of body weight and appetite in infants and toddlers with cystic fibrosis.

Appetite·2024

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

Spontaneous resolution of diffuse persistent pulmonary interstitial emphysema.

Mandeep S Jassal¹, Jane E Benson, Peter J Mogayzel

¹Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.

Pediatric Pulmonology

|April 25, 2008

Summary

Persistent pulmonary interstitial emphysema (PPIE) in infants can sometimes resolve spontaneously. This finding suggests conservative management may be suitable for some cases, avoiding surgery.

More Related Videos

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Related Experiment Videos

Last Updated: Jul 5, 2026

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Pediatric Pulmonology
Neonatal Medicine
Radiology

Background:

Persistent pulmonary interstitial emphysema (PPIE) is a rare neonatal lung condition.
It involves air entering the lung's interstitial space due to alveolar basement membrane disruption.
PPIE can mimic other congenital cystic lung lesions.

Purpose of the Study:

To report a case of extensive bilateral PPIE with persistent pneumomediastinum.
To evaluate the efficacy of conservative management in such cases.
To challenge the assumption that surgical resection is always necessary for localized PPIE.

Main Methods:

Case report of an infant with extensive bilateral PPIE and persistent pneumomediastinum.
Utilized CT scans for diagnosis and monitoring.
Documented the clinical course under conservative management.

Main Results:

The infant's extensive bilateral PPIE and persistent pneumomediastinum resolved spontaneously.
Conservative management was successful without surgical intervention.
CT findings were crucial for differentiating PPIE from other conditions.

Conclusions:

Extensive bilateral PPIE with persistent pneumomediastinum can resolve spontaneously.
Conservative management may be appropriate for select pediatric cases of PPIE.
Surgical intervention might not always be required for localized PPIE.